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Gluten and Neuro-Degenerative Disease
A case of celiac disease mimicking amyotrophic lateral sclerosis.
Turner MR, Chohan G, Quaghebeur G, Greenhall RC, Hadjivassiliou M, Talbot K. Nat Clin Pract Neurol. 2007 Oct;3(10):581-4.
Department of Neurology, John Radcliffe Hospital, Oxford, UK.
BACKGROUND: A 44-year-old male presented to a general neurology clinic with a 6-month history of progressive right-sided spastic hemiparesis without sensory symptoms or signs. The thigh muscle in the affected leg showed signs of wasting. The patient had a remote family history of celiac disease.
INVESTIGATIONS: Neurological examination, neurophysiological studies, brain MRI scan, routine blood tests, duodenal biopsy, cerebrospinal fluid analysis including polymerase chain reaction test for JC virus DNA, serological testing for HIV and for the presence of serum antibodies to endomysium, gliadin and tissue transglutaminase.
DIAGNOSIS: Celiac disease with neurological involvement, mimicking amyotrophic lateral sclerosis.
MANAGEMENT: Strict gluten-free diet.
Lou Gehrig Loved Wheaties
Lou Gehrig was the first athlete to be pictured on the Wheaties box. Lou Gehrig also died of ALS (amyotrophic lateral sclerosis), which is commonly known as Lou Gehrig's disease. What if he had a gluten sensitivity?
(Reference: Datis Kharrizian, 2010-Mastering the Thyroid)
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